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DDS | Interleaving Device

Simultaneous and Interleaved Acquisition of NMR Signals from Different Nuclei with a Clinical MRI Scanner.

  • High SNR for short measurement time
  • Exchangeable RF-coils for different core sizes
  • Low echo times allow short T2 measurements
  • Precise sample positioning system for long cores
  • High power 1D gradient for core profile measurements
  • Complete 3D gradient system for imaging
  • Sample diameter up to 72 mm (2.8 inches)up to 100 MHz

Description

Our PD-DDS frequency synthesizer is an upgrade for Siemens MRI scanners that will enable truly simultaneous or rapidly interleaved (i.e. within the same pulse sequence) acquisition of signal from two different nuclear species. It is designed for Siemens MRI systems fitted with the MNO (multinuclear) option running the VB platform (e. g. Avanto, TIM Trio, 7T). The approach is general; therefore, the device may potentially be applied with other manufacturers’ MRI scanners.
Using the PD-DDS will overcome the limitation of acquiring only one signal from only one nuclear species per pulse sequence.


This enables, for example, the implementation of:

  • Interleaved acquisition of 13C or 31P and 1H spectra or images.
  • 31P CSI interleaved with 1H navigators for online motion correction or dynamic shimming.
  • Simultaneous acquisition of 23Na and 1H images for improved 23Na image reconstruction.
  • And potentially other applications.

THIS PRODUCT IS NOT MEANT FOR ANY MEDICAL USE AND MAY NOT BE USED ON HUMANS OR ANIMALS.

The PD-DDS device can be installed or removed from the scanner in approximately a minute, requiring only a few cable connections to be changed. When the installed device is powered off, the MRI scanner will work the same way as if the device was removed. Only the receive chain of the scanner is modified; the safety-critical transmit chain is not changed in any way, so the device has no implications for RF safety supervision. The device is compatible with all multinuclear-capable RF coils, requiring no alteration to their hardware, leaves the scanner’s performance unchanged and is fully transparent to normal scanner operation. It may be used with anything from a simple single-channel coil to more complex multichannel receive arrays.

How it works

The device is connected to the scanner receive chain. Before running a sequence, the device is programmed with the operating frequency for the particular nucleus. The device operates in two modes: passive and active. When passive, the scanner receive channels operate as normal, with no performance degradation. When the device is active, the receive channel detection frequency is altered to detect signal from the second nucleus of interest. The device is switched between passive and active modes within milliseconds under control of the pulse sequence, which is programmed by the user.

Publications

Simultaneous and Interleaved Acquisition of NMR Signals from Different Nuclei with a Clinical MRI Scanner Martin Meyerspeer , Arthur W. Magill, Andre Kuehne, Rolf Gruetter, Ewald Moser, and Albrecht Ingo Schmid Magnetic Resonance in Medicine 76:1636–1641 (2016)

Read full text here: http://onlinelibrary.wiley.com/doi/10.1002/mrm.26056/pdf

Number of channels4
Synthesizer
Frequency range10 MHz to 350 MHz
Frequency resolutionapprox. 3.55 µHz (1e9 / 2^48 Hz)
IOs
LO 1-4 inputs4 (LEMO ERN.00.250.CTL)
LO 1-4 outputs4 (LEMO ERN.00.250.CTL)
Maximum input power6 dBm
Maximum output power0 dBm
ENABLE IN / OUT 22 (LEMO ERN.00.250.CTL)
Enable high voltage2.5 V to 5.5 V (active)
Enable low voltage-0.5 V to 1 V (inactive)
Enable delay5 µs (relay mode fast), 5 ms (relay mode slow)
Reference Clock REFCLK IN / OUT 22 (LEMO ERN.00.250.CTL)
Reference clock input power3 dBm (2 dBm to 6 dBm)
Reference clock input frequency10 MHz
Misc 
Power supply2 USB 2.0 or USB 3.0 ports of a PC
LEDsPower (green) , Active / ENABLE IN > 2.5 V (yellow)
Dimensions25 cm x 18 cm x 3 cm / 6HUx6HPx180mm
Weight< 1 kg

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